According to a received doctrine, espoused, by Karl Popper and Harry Collins, and taken for granted by many others, poorly replicated evidence should be epistemically defective and incapable of persuading scientists to accept the views it is used to argue for. But John Hughlings Jackson used poorly replicated clinical and post-mortem evidence to mount rationally compelling and influential arguments for a highly progressive theory of the organization of the brain and its functions. This paper sets out a number (...) of Jackson's arguments from his evidence and argues that they constitute a counter example against the received doctrine. (shrink)

Understanding terrestrial carbon metabolism is critical because terrestrial ecosystems play a major role in the global carbon cycle. Furthermore, humans have severely disrupted the carbon cycle in ways that will alter the climate system and directly affect terrestrial metabolism. Changes in terrestrial metabolism may well be as important an indicator of global change as the changing temperature signal. Improving our understanding of the carbon cycle at various spatial and temporal scales will require the integration of multiple, complementary and independent methods (...) that are used by different research communities. Tools such as air sampling networks, inverse numerical methods, and satellite data allow us to study the strength and location of the global- and continental-scale carbon sources and sinks. Bottom-up studies provide estimates of carbon fluxes at finer spatial scales and examine the mechanisms that control fluxes at the ecosystem, landscape, and regional scales. Bottom-up approaches include comparative and process studies that provide the necessary mechanistic information to develop and validate terrestrial biospheric models. An iteration and reiteration of top-down and bottom-up approaches will be necessary to help constrain measurements at various scales. We propose a major international effort to coordinate and lead research programs of global scope of the carbon cycle. (shrink)

Darwinism, Democracy, and Race examines the development and defence of an argument that arose at the boundary between anthropology and evolutionary biology in twentieth-century America. In its fully articulated form, this argument simultaneously discredited scientific racism and defended free human agency in Darwinian terms. The volume is timely because it gives readers a key to assessing contemporary debates about the biology of race. By working across disciplinary lines, the book's focal figures--the anthropologist Franz Boas, the cultural anthropologist Alfred Kroeber, the (...) geneticist Theodosius Dobzhansky, and the physical anthropologist Sherwood Washburn--found increasingly persuasive ways of cutting between genetic determinist and social constructionist views of race by grounding Boas's racially egalitarian, culturally relativistic, and democratically pluralistic ethic in a distinctive version of the genetic theory of natural selection. Collaborators in making and defending this argument included Ashley Montagu, Stephen Jay Gould, and Richard Lewontin. Darwinism, Democracy, and Race will appeal to advanced undergraduates, graduate students, and academics interested in subjects including Philosophy, Critical Race Theory, Sociology of Race, History of Biology and Anthropology, and Rhetoric of Science. (shrink)

John Hughlings Jackson is a major figure at the origins of neurology and neuroscience in Britain. Alongside his contributions to clinical medicine, he left a large corpus of writing on localisation of function in the nervous system and other theoretical topics. In this paper I focus on Jackson’s “doctrine of concomitance”—his parallelist theory of the mind-brain relationship. I argue that the doctrine can be given both an ontological and a causal interpretation, and that the causal aspect of (...) the doctrine is especially significant for Jackson and his contemporaries. I interpret Jackson’s engagement with the metaphysics of mind as an instance of what I call meta-science—the deployment by scientists of metaphysical positions and arguments which help streamline empirical investigations by bracketing off unanswerable questions and focussing attention on matters amenable to the current tools of experimental research. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

The “function debate” in the philosophy of biology and the “venom debate” in the science of toxinology are conceptually related. Venom systems are complex multifunctional traits that have evolved independently numerous times throughout the animal kingdom. No single concept of function, amongst those popularly defended, appears adequate to describe these systems in all their evolutionary contexts and extant variations. As such, a pluralistic view of function, previously defended by some philosophers of biology, is most appropriate. Venom systems, like many other (...) functional traits, exist in nature as points on a continuum and the boundaries between “venomous” and “non-venomous” species may not always be clearly defined. This paper includes a brief overview of the concept of function, followed by in-depth discussion of its application to venom systems. A sound understanding of function may aid in moving the venom debate forward. Similarly, consideration of a complex functional trait such as venom may be of interest to philosophers of biology. (shrink)

The title should read Ever New Flights’ of Creativity: Nāda-yoga and Improvisation.

In these essays, J.L. Mehta, Indian philosopher in whose life and work East and West met profoundly, reflects on the origins and potency of modern hermeneutics and phenomenology, and applies the principles of interpretation to Hindu traditions. These farseeing essays show a hopeful way for non-Western cultures to gain insight into the basic presuppositions of the Western world, and to reclaim their own origins and ways of thinking, and to participate in an emerging planetary thinking.

How should doctors respond to requests from parents of terminally ill children for unproven treatments to be tried? Here it is argued that doctors faced with difficult cases where (1) it is not obviously against a child's interests to undergo an unproven treatment and (2) provided the treatment does not draw extravagantly on NHS funds, it may be appropriate, though not necessarily obligatory, for doctors to comply. It is important to recognise that often there may not be 'the right response'--only (...) alternative appropriate responses. (shrink)

Introduction While quizzing during informed consent for research to ensure understanding has become commonplace, it is unclear whether the quizzing itself is problematic for potential participants. In this study, we address this issue in a multinational HIV prevention research trial enrolling injection drug users in China and Thailand. Methods Enrolment procedures included an informed consent comprehension quiz. An informed consent survey followed. Results 525 participants completed the informed consent survey (Heng County, China=255, Xinjiang, China=229, Chiang Mai, Thailand=41). Mean age was (...) 33 and mean educational level was 8 yrs. While quizzing was felt to be a good way to determine if a person understands the nature of clinical trial participation (97%) and participants did not generally find the quiz to be problematic, minorities of respondents felt pressured (6%); anxious (5%); bored (5%); minded (5%); and did not find the questions easy (13%). In multivariate analysis, lower educational level was associated with not minding the quizzing (6–10 yrs vs 0–5 yrs: OR=0.27, p=0.03; more than 11 yrs vs 0–5 yrs: OR=0.18, p=0.03). There were also site differences (Heng County vs Xinjiang) in feeling anxious (OR=0.07; p=<0.01), not minding (OR=0.26; p=0.03), being bored (OR=0.25; p=0.01) and not finding the questions easy (OR=0.10; p=<0.01). Conclusions Quizzing during the informed consent process can be problematic for a minority of participants. These problems may be associated with the setting in which research takes place and educational level. Further research is needed to develop, test and implement alternative methods of ensuring comprehension of informed consent. Trial Registration clinicaltrials.gov number NCT00270257. (shrink)

This inquiry explores the terms yogakshema, sampradaya, and manodharma sangita, as well as theories and practices of improvisation and innovation in music and other fields of Hindu culture. It considers the ways Hindu traditions play out the human contradiction—that life must always combine both old and new; the ways improvising is part of the Hindu frameworks in Vedic chanting, and the performance of ragas and other cultural activities in India. Both set patterns and nuanced interpretations in literary and musical works (...) present processes which suggest models of progress and renewal in various fields of human endeavor. I am unpacking the scholar V. Raghavan’s ideas about how traditions in Indian culture can adapt creatively in time. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Dostoevsky, Girard, LevinasApocalyptic Frenzy and Eschatological Ethics in Dostoevsky's DevilsJ. A. Jackson (bio)In his interview with René Girard, Benoît Chantre connects the mimetic theory of René Girard with the ethics of Emmanuel Levinas, observing, "It is in the confrontation with otherness that the individual acquires self-consciousness. The self has no meaning except in the relationship, even when the relationship takes the form of a duel. Can we not (...) say, following Levinas, that only experience of war can allow us to think about reconciliation?" Girard concurs and expands: "According to what you have said, Levinas saw the duel, like love, as an escape from totality that we absolutely need. However, it is in this sense that it explodes totality…. By affirming that the duel is already the relationship to the Other, it shows that the relationship sits at the heart of violent reciprocity."1 How fitting that a discussion regarding the thought of Girard and Levinas should center at some point on the duel, an act of violence, of course, and yet an event also pregnant with ethical implications, as rivals must respond face-to-face. Perhaps we should not be so surprised that our two thinkers should fashion the duel as both a temptation to murder and the command "Thou shalt [End Page 227] not murder"; both men have a deep love and sense of indebtedness to the Russian novelist Fyodor Dostoevsky, a man in whose works the duel—both literal and relational—often plays a crucial narrative, and penitential, role.As the conversation between Chantre and Girard reveals, the pairing of Girard and Levinas seems wholly natural and still much underappreciated.2 Dostoevsky seems to be a natural interlocutor, as one cannot help but feel Dostoevsky's hyperbolic excessiveness coursing through the works of both Girard and Levinas. To read Dostoevsky now, thanks to Girard, one cannot help but be dazzled by Dostoevsky's genius regarding mimetic desire and modern man's underground psychology, the very foundations for Girard's notion of the Apocalyptic. To read Levinas means having the notion of infinite responsibility illumined by Dostoevsky's beautiful religious meditations, where previously one may have only seen Dostoevsky's relishing the idea of the impossible, a mixture of monastic asceticism, Karamozovan passion, and Dostoevsky's own romantic proclivities.3 In this essay, I wish to pursue a reading of Dostoevsky's Devils with Girard's thoughts on apocalypticism and mimetic frenzy—with its inherent focus on the human "political" community—on one side. This is, in turn, partnered with Levinas's sense of the eschatological as an anarchic response to history and politics, with ethics being prior to both politics and history. Most importantly, however, I want to offer my own reading of Dostoevsky and investigate his own position inside of this exchange. To this end, alongside Levinas's idea of eschatology, especially as spelled out in Totality and Infinity, and Girard's often understated, yet very-much-present notion of positive mimesis (love), I also investigate Dostoevsky's notion of kenosis, a key idea in Dostoevsky's anthropology, psychology, and theology.René Girard has always maintained that he did not invent his mimetic theory—that he simply needed only to listen to what great authors like Cervantes, Dante, Shakespeare, Proust, and, especially, Dostoevsky had to say about desire. Indeed, Dostoevsky maintains a central position in Girard's first book, Deceit, Desire and the Novel, and is his only subject matter in Resurrection from the Underground. The connection between Girard and Dostoevsky became even more profound for Girard: "When I wrote the last chapter of my first book, I had a vague idea of what I would do, but as the chapter took form I realized I was undergoing my own version of the experience I was describing. I was particularly attracted to the Christian elements, for example, Stepan Verkhovensky's final journeys and turn to the Gospel before his death. So I began to read the Gospels and the rest of the bible. And I turned into a Christian."4 One can find in much of Girard's meditations on Dostoevsky the seeds of so many [End Page 228] of his... (shrink)

Is conceptual analysis required for reductive explanation? If there is no a priori entailment from microphysical truths to phenomenal truths, does reductive explanation of the phenomenal fail? We say yes . Ned Block and Robert Stalnaker say no.

Del Giudice's model of sex-specific attachment patterns demonstrates the usefulness of infusing life history theory with principles of sexual selection. We believe a full synthesis between the two theories provides a foundation for a comprehensive model of alternative reproductive strategies. We extend Del Giudice's ideas based on our own program of research, focusing specifically on the importance of intrasexual competition and the individual phenotype during development.

In lieu of an abstract, here is a brief excerpt of the content:"And They Sang A New Song":Reading John's Revelation From The Position Of The LambJ.A. Jackson (bio) and Allen H. Redmon (bio)Then one of the elders said to me, "Do not weep. See, the Lion of the tribe of Judah, the Root of David, has conquered, so that he can open the scroll and the seven seals." Then I saw between the throne and the four living creatures and (...) among the elders a Lamb standing as if it had been slaughtered.—Revelation 5:5–6In an interview with Markus Müller, René Girard asserts the importance of taking into account the apocalypticism of Christianity. Apocalypse, Girard reminds us, "means revelation: apocalypto means to open up and to show the truth. But it also means absolute violence, so the apocalypse is a violent revelation and a revelation of violence" (Girard 1996). That the Revelation is a violent revelation has been well established. Despite textual evidence that would beg those who approach the text to do just the opposite, readers have fixated on the violence of the Revelation since its inception, finding in it God's final retribution against those who persecute the Church.1 Commentators such as Dennis E. Johnson, William Hendricksen, and George Elden Ladd have produced recent, full-length commentaries that champion the appearance of a Christ in Revelation ready to establish himself as a military champion and exact his revenge on those who persecute him (see, for example, Johnson 2001; Hendricksen 1998; and Ladd 1993). These accounts, and those that follow suit, are blinded by the violent revelation of John's apocalyptic narrative and fail to see the poem's revelation of violence—the other, prophetic half of what Girard rightly contends exists in Christian apocalypse.This error is understandable to some extent. Read in its own light and apart from the Gospel revelation as understood by those familiar with mimetic [End Page 99] theory, one has no hermeneutical principle for recognizing the end to which John is writing. The victims of the text can be ignored in the precise way that all victims are disregarded when the scapegoat mechanism functions properly. Such should not be the case in the Revelation, though, a text in which the scapegoat mechanism is exposed and pushed to its logical conclusions. John offers his reader a glimpse into the way this mechanism will function when all that is left is wall-to-wall violence, when one is left with only two alternatives: succumb to the mechanism and reciprocate its violence, or extricate oneself through nonreciprocation (and potentially die).In the margins of the violent revelation in John's apocalyptic vision, a revelation of violence emerges that can expose humankind's potential to annihilate itself and the mechanism with which it will do so. When read through the lens of mimetic theory, one discovers that John's narrative delivers a revelation of violence, an explicit naming and unmasking of the sacrificial mechanism that can capture for the reader not only the machinations of the sacrificial apparatus but one's own potential participation in it as well. As such, the poem can posit itself as a commandment (a Thou-shall-not-murder) that ultimately refuses the temptation to respond to violence in violence.The fact that John uses the apocalyptic to present this directive should not be surprising. Girard writes: "Only through the mediation of the scapegoat mechanism can violence become its own remedy, and the victimage mechanism can only be triggered by the frenetic paroxysm of the 'crisis.' This means that the violence, having lost its vitality and bite, will paradoxically be more terrible than before its decline. As the whole of humanity makes the vain effort to reinstate its reconciliatory and sacrificial virtues, this violence will without doubt tend to multiply its victims, just as happened in the time of the prophets" (Girard 1978, 195–96). While Girard's commentary on biblical eschatology and apocalypse refers mainly to the scapegoat mechanism as it applies to and is revealed in the Gospel texts, we see the immediacy and the frenzy of the apocalyptic and the ubiquitous violent mimetic appropriations also performed in John's Revelation.2 John captures... (shrink)

Does it signify morally whether a deception is achieved by a lie or some other way? David Bakhurst has challenged my view that it can signify. Here I counter his criticisms--firstly, by clarifying the terminology: What counts as a lie? Secondly, by exploring further what makes lying wrong. Bakhurst maintains that lying is wrong in that it infringes autonomy--and other deceiving stratagems, he says, do so equally. I maintain that lying is wrong in that it endangers trust--and other types of (...) deceiving stratagems do not do so equally. Lying to patients, I contend, is an abuse of their trust. Other forms of their intentional deception need not be so, although, in our autonomy-minded culture, they are likely to be so. (shrink)

The succeeding pages were destined, had matters gone otherwise, to form one section of a chapter devoted to the text of those deservedly neglected authors whom, after a mortal illness released Anton Westermann from the task, Rudolf Hercher marshalled between the two covers of the Didot Epistolographi. That chapter, in its turn, was to have been the last in a volume of Adversaria, and, if the truth is to be told, perhaps not the least important function of some of my (...) proposals was to supply a colourable pretext for dealing with passages of other writers whom I had not treated in the body of the book. (shrink)

What does feminism have to do with nanotechnology? And how do mad scientists demonstrate the connections between the two? To explore this, I examine a case study of mad scientists in film, discussing first why mad scientist images arise and why nanotechnology, or the manipulation of matter on the atomic and molecular scales, may be particularly vulnerable to this kind of representation. National funding agencies are calling for the integration of ethics and societal implications into nanoscience and technology research and (...) the training of future scientists and engineers. This emphasis offers a powerful way to break down stereotypes about science and engineering that discourage the participation of some groups. (shrink)

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A review of research addressing correlates of attitudes toward social responsibility of business leads to the conclusion that little can currently be confidently stated concerning such correlates and that progress toward the understanding of relevant linkages is largely dependent on the development of psychometrically adequate indices of social attitudes. Using a sample of high level executives from a large number of industries, this paper examines various psychometric properties of an index of social attitudes, the Social Attitudes Questionnaire (SAQ) (Aldag and (...) Jackson, 1977) and considers relationships of SAQ subscale scores to multiple measures of firm size and economic performance and to managerial demographic and social psychological characteristics. Results of this study reflect favorably on psychometric integrity of the SAQ and reveal a complex set of correlates of its subscales. (shrink)